Yamagishi K, Iso H, Tanigawa T, Cui R, Kudo M, Shimamoto T : High sodium intake strengthens the association between angiotensinogen T174M polymorphism and blood pressure levels among lean men and women: a community-based study. Shiraki K, Une K, Yano R, Otani S, Mimeoka A, Watanabe H : Inhibition by long-term fermented miso of induction of pulmonary adenocarcinoma by diisopropanolnitrosamine in Wistar rats. Ohuchi Y, Myojin Y, Shimamoto F, Kashimoto N, Kamiya K, Watanabe H : Decrease in size of azoxymethane induced colon carcinoma in F344 rats by 180-day fermented miso. Ohara M, Lu H, Shiraki K, et al: Inhibition by long-term fermented miso of induction of gastric tumors by N-methyl- N′-nitro- N-nitrosoguanidine in CD (SD) rats. Ohara M, Lu H, Shiraki K, et al: Prevention by long-term fermented miso of induction of colonic aberrant crypt foci by azoxymethane in F344 rats. Ohara M, Lu H, Shiraki K, et al: Radioprotective effects of miso (fermented soy bean paste) against radiation in B6C3F1 mice: increased small intestinal crypt survival, crypt lengths and prolongation of average time to death. Messina MJ, Persky V, Setchell KDR, Barnes S : Soy intake and cancer risk: a review of the in vitro and in vivo data. Masaoka Y, Watanabe H, Katoh O, Dohi K : Effects of miso and NaCl on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. Watanabe H, Uesaka T, Kido S, et al: Influence of concomitant Miso or NaCl treatment on induction of gastric tumors by N-methyl- N′-nitro- N-nitorosoguanidine in rats. Ogundigie PO, Roy G, Kanin G, Goto T, Ito A : Effect of biochanin A or testosterone on liver tumors induced by a combined treatment of DEN and fission neutrons in BCF1 mice. Ito A, Watanabe H, Basaran N : Effects of soy products in reducing risk of spontaneous and neutron-induced liver tumors in mice. Watanabe H, Takahashi T, Ishimoto T, Ito A : The effect of miso diet on small intestine damage in mice irradiated by X-ray. These results show that blood pressure was not increased by the miso diet. Nephropathy was observed in both sexes of Dahl rats but not SD rats. SBP in female Dahl rats on 2.3% NaCl was significantly increased from 8 weeks after treatment. Thereafter, SBP and DBP in both the high NaCl groups were significantly increased when compared with the MF or miso group. DBP in male Dahl rats was significantly increased by the 2.3% NaCl diet as compared with that in the MF group ( p<0.01) or miso group ( p<0.05) from 4 weeks of treatment. The rats were autopsied after 12 weeks on a diet. The systolic and diastolic blood pressures (SBP/DBP) were measured at 2, 4, 8 and 12 weeks of treatment with a miso diet including 2.3% NaCl, a high-sodium diet including 2.3% or 1.9% NaCl, or a normal diet including 0.3% NaCl (MF diet Oriental Yeast Co., Tokyo, Japan). The purpose of this study was to compare the effects of miso and sodium chloride (NaCl) on blood pressure in both sexes of Dahl and SD rats.
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